Hematologic, Immunologic, and Neoplastic Disorders Practice Test

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• Which immunophenotype is characteristic of CLL?
• In immune thrombocytopenia, platelets are typically less than which value?
• In a splenic sequestration crisis, what happens to the blood?
• A patient with bone pain, anemia, and renal impairment has an M-protein spike on SPEP. What is the most likely diagnosis?
• Jenai was bitten by a tick and now has petechiae, blood in the stool, and spontaneous nosebleeds; labs show a decreased platelet count. Which disorder is most likely?
• Which presentation is typical for Hodgkin lymphoma in a adolescent?
• Which of the following is a non-CRAB feature in plasma cell disorders?
• Which of the following conditions is NOT listed as a chronic disease causing anemia?
• What is the priority nursing care for this patient with Hemophilia A presenting with head trauma?
• In the leukemia diagnostic process, which action is appropriate to include?
• Which finding supports increased intracranial pressure in an adolescent with head injury?
• What is the normal hematocrit range?
• A 12-month-old presents with poor muscle tone, irritability, concave nailbeds, and edema. Which disorder is most consistent with these findings?
• Which of the following lists common bleeding manifestations in ITP?
• What is the normal hematocrit range?
• Platelet transfusion refractoriness is most commonly due to what?
• Which assessment should be avoided if Wilms tumor is suspected?
• Ewing sarcoma most commonly involves which bone?
• CAR-T cell therapy: concept and approved indications.
• Imatinib: mechanism and primary indication.
• Which chromosomal translocation is characteristic of chronic myeloid leukemia?
• Which of the following is NOT a typical presenting finding in hemophilia?
• Adult hematologic levels for RBCs are reached during which period?
• Which statement best describes the role of hydration in preventing crises in sickle cell disease?
• In severe combined immunodeficiency (SCID), what is the major immunologic defect and the standard treatment approach?
• Which of the following is a CRAB feature of multiple myeloma?
• Which statement correctly identifies the interpretation of an ANC of 480 cells/µL?
• Which description best captures bone involvement in sickle cell disease?
• What is a core component of acute promyelocytic leukemia (APL) treatment?
• Hyperviscosity syndrome in Waldenström macroglobulinemia is most commonly due to which immunoglobulin?
• What cells are pathognomonic on biopsy for Hodgkin lymphoma?
• Koilonychia (concave nailbeds) is a classic sign of which condition in children?
• Vaccination considerations for immunocompromised patients and household contacts are best described as:
• During neutropenic precautions, what is the best response to a visitor bringing garden flowers?
• What is the normal hemoglobin range?
• Tonya is a 16-year-old African American girl with pain in both hands, chest pain, fever, and moderate respiratory distress; she is receiving IV hydration and hydroxyurea. Which disorder does she most likely have?
• Which statement about clotting factor levels in infancy is true?
• Features of X-linked agammaglobulinemia: which immunoglobulins are reduced and typical age of presentation?
• During a well-child exam, a 3-year-old girl with known hearing loss and developmental delays lives in an old house with copper pipes and chipped paint. She reports abdominal pain, vomiting, constipation, and headaches. What condition is suspected?
• How does the Lugano staging system differ from Ann Arbor for lymphomas?
• Which agent is an alternative to allopurinol for uric acid control in tumor lysis syndrome?
• Sickle cell disease pathophysiology: what mutation and what is the most common acute hospitalization cause in adults?
• Acute chest syndrome is a serious complication most commonly seen in which disorder?
• For PRBC transfusion, which action is appropriate when starting the transfusion?
• What happens to the red blood cell count after the newborn begins breathing air?
• What defines the Ann Arbor staging A vs B in lymphoma?
• Which of the following is a common sign of iron deficiency anemia in infants?
• Which statement about tumor lysis syndrome pathophysiology is NOT true?
• RBC levels decline to approximately what range by 2-3 months of age?
• In sickle cell disease, hydroxyurea is used to reduce the frequency of which complication?
• In anemia, which test result would typically be decreased?
• Which clinical manifestation is most characteristic of thrombocytopenia in a child?
• What are the two major categories of lymphoma and a hallmark difference between them?
• CAR-T cell therapy typically targets which B-cell antigen?
• In managing sickle cell disease, which measure is central to reducing crises?
• Which practice supports activity tolerance in a child with sickle cell disease?
• By about how long do WBC counts stabilize after birth?
• The therapeutic management of children with sickle cell disease primarily consists of which of the following?
• A patient has microcytic anemia with low ferritin and high TIBC. What is the most likely diagnosis and first-line treatment?
• During a vaso-occlusive crisis in a child with sickle cell disease, which intervention most improves tissue perfusion?
• Beta-thalassemia is most commonly found in which regions?
• For splenic sequestration crisis in sickle cell disease, which treatment is listed?
• Iron studies pattern in iron deficiency anemia shows which combination?
• Which laboratory pattern indicates hemolysis with intravascular involvement (low haptoglobin, high LDH, high indirect bilirubin, reticulocytosis)?
• In chronic myeloid leukemia, which translocation is characteristic and what drug targets it?
• Priapism in sickle cell disease is an emergency because it can cause tissue damage due to microcirculatory obstruction. Which statement is true?
• Immune thrombocytopenia commonly presents after which event?
• Reticulocyte production index interpretation in anemia states which of the following is correct?
• Which coagulation test is typically prolonged in hemophilia?
• A common skin complication seen in sickle cell disease is which of the following?
• Graft-versus-host disease: what is it and which transplant setting carries the highest risk?
• Normal thrombin time (TT) range?
• Which intervention is commonly used in the care of a child with sickle cell disease?
• Doug, 12, experiences frequent nosebleeds, easy bruising, and blood in the urine; his parents discourage him from contact sports due to his condition. Which disorder best explains his symptoms?
• Which care practice would you anticipate when planning the shift for a child with leukemia?
• A 60-year-old presents with fatigue and macrocytic anemia with hypersegmented neutrophils. What is the most likely deficiency and the initial confirmatory test?
• What is the classic triad of acute graft-versus-host disease manifestations?
• Which drug is a BCR-ABL tyrosine kinase inhibitor used in CML?
• Non-Hodgkin lymphoma is best described as what?
• In thrombocytopenia, what is the typical prophylactic platelet transfusion threshold?
• Which statement describes iron deficiency anemia treatment?
• In sickle cell disease, which organ and finding is described by infarcts leading to fibrosis and increased infection risk?
• Which tests assess the extrinsic and intrinsic pathways of coagulation, respectively?
• In early life, when is the WBC count highest?
• Which leukemia is most common in children?
• Which infection-control practice is appropriate for a leukemia patient to reduce infection risk?
• In Lugano staging, which imaging modality is used for response assessment?
• Aplastic crisis in sickle cell disease is typically triggered by which factor?
• Which statement best differentiates acute myeloid leukemia (AML) from acute lymphoblastic leukemia (ALL)?
• Which factors place this patient at increased risk for injury?
• Which laboratory finding will be abnormal in a child with hemophilia?
• What is the hallmark serum protein electrophoresis finding in multiple myeloma?
• In managing a child with sickle cell disease, which therapy would you include?
• For administering liquid oral iron to a child, which method is recommended to avoid staining the teeth?
• Which of the following is a precipitating factor for a sickle cell crisis?
• Spleen involvement in sickle cell disease is characterized by infarcts leading to fibrosis and increased infection risk. Which option reflects this description?
• Which finding may be present in Wilms tumor?
• Where is hematopoiesis occurring at birth?
• Auer rods are associated with which leukemia and what do they indicate?
• What is a recognized strategy to reduce painful crises in sickle cell disease?
• Explain the mechanism and management of heparin-induced thrombocytopenia (HIT).
• A 4-year-old with decreased leukocytes, platelets, and erythrocytes was admitted for a chicken pox infection that will not go away. Which diagnosis best fits these findings?
• Which statement about absolute neutrophil count (ANC) is true?
• WBC counts decline after how many hours post-birth?
• What is the Lugano classification used for?
• Five-year-old Roxy presents with failure to thrive, lymphadenopathy, oral candidiasis, and diarrhea. Which diagnosis best fits these findings?
• Vitamin K is required for synthesis of which clotting factors?
• In sickle cell disease, which ocular complication is commonly observed?
• Which tumor markers are associated with pancreatic and ovarian cancers?
• Which laboratory finding is most associated with acute intravascular transfusion reaction?
• During chemotherapy administration for leukemia, which action is appropriate?
• What is the normal range for red blood cell count in a healthy child?
• What is von Willebrand disease and how is it diagnosed?
• Iron studies in anemia of chronic disease show which pattern?
• Alpha-thalassemia is most commonly found in which geographic regions?
• MGUS vs smoldering myeloma: which statement is correct?
• Differentiate PT/INR and aPTT in terms of pathways assessed and clinical uses?
• During rounds, a pediatric patient awaiting a bone marrow biopsy has a low reticulocyte count and thrombocytopenia. Which diagnosis is most consistent with these findings?
• M-spike on serum protein electrophoresis indicates which type of disease?
• In sickle cell disease, cerebrovascular accidents involve which organ primarily?
• The nurse calculates the absolute neutrophil count (ANC) using Band percent plus Seg percent times total WBC. If the CBC shows WBC 1.5 x 10^3/µL with bands 3% and seg 29%, what is the ANC and classification?
• What is the normal platelet count range?
• Which nursing action is appropriate for a child with thrombocytopenia?
• Which laboratory test most directly assesses the extrinsic coagulation pathway?
• What is the first-line therapy for diffuse large B-cell lymphoma?
• Flow cytometry in leukemia/lymphoma classification primarily provides immunophenotyping to identify which of the following?
• In a 10-year-old with Hemophilia A who has not received factor for a year and experiences head trauma, which complication is most likely?
• What is the mechanism by which allopurinol helps prevent uric acid buildup in tumor lysis syndrome?
• Febrile nonhemolytic transfusion reaction vs acute hemolytic transfusion reaction: distinguishing features.
• Which finding is common in iron deficiency anemia?
• Which statement describes the typical presentation and immunophenotype of chronic lymphocytic leukemia (CLL) compared with small lymphocytic lymphoma (SLL)?
• Why is vitamin K administered at birth?
• Which statement about the role of PET-CT in lymphoma response assessment is true?
• What is an appropriate approach when preparing a child for a bone marrow aspiration?
• ABO transfusion incompatibility: typical reaction timing and presentation?
• Name two major beta/thalassemia types and typical geographic prevalence.
• A 4-year-old with a swollen abdomen and good appetite is most likely to have which diagnosis?
• Normal fibrinogen range?
• Vaccines in immunocompromised patients: which vaccines are contraindicated?
• Common adverse effects of alkylating chemotherapeutic agents.
• Which condition is most commonly evaluated by ferritin levels as an indicator?
• Which presentation signs are typical in leukemia?
• Which sport should be encouraged for safe participation after stabilization of a patient with Hemophilia A?
• Which item is commonly addressed in post-operative education for osteosarcoma?
• During a PRBC transfusion, which monitoring step is recommended in the first minutes of the infusion?
• Which renal manifestations are typical of sickle cell disease?
• Rituximab: target and a major infection risk.
• In suspected vitamin B12 deficiency, which additional lab finding supports the diagnosis besides low serum B12?
• In infants, cow's milk should be limited until at least what age?
• Which statement is true regarding iron deficiency anemia management in infants?
• Which statement correctly describes initial management of tumor lysis syndrome?
• Prolonged anemia in pediatric patients may present with which combination?
• Which biomarkers are used in staging myeloma with the ISS system?
• An older child with immunodeficiency and oral candidiasis is most concerning for which diagnosis?
• Ewing sarcoma can occur in any bone; usually the femur; what are typical presenting features?
• HIV infection progression and impact of antiretroviral therapy.
• Which statement best defines anemia?
• In SCID, which lymphocyte development is defective?
• Which statement about hemophilia care is true?
• Which symptom would you most likely report in a child with a suspected cancer diagnosis?
• How do ferritin and transferrin saturation help distinguish anemia of chronic disease from iron deficiency anemia?
• Which statement accurately describes the inheritance of hemophilia A and B?
• Which condition is characterized by pancytopenia with hypocellular bone marrow?
• Waldenström macroglobulinemia hallmark and its clinical consequence is best described as which of the following?
• Hyperviscosity symptoms in this disorder can include which of the following? (Choose the best specific symptom listed)
• In addition to bone pain, which symptom is commonly reported with Ewing sarcoma?
• Which diagnostic procedure is used to obtain cerebrospinal fluid in leukemia evaluation?
• A 30-year-old presents with pallor, fatigue, pancytopenia, and a hypocellular bone marrow. What is the most likely diagnosis?
• DIC is defined as what, and name two common triggers?
• Normal prothrombin time (PT) range?
• Which finding is most characteristic of aplastic anemia?
• Reed-Sternberg cells on biopsy are characteristic of which lymphoma?
• Normal activated partial thromboplastin time (aPTT) range?
• Which feature distinguishes Hodgkin lymphoma from most non-Hodgkin lymphomas?
• What is the best initial nursing action when a child with Hemophilia A presents with a concussion?
• Which targeted therapy is used to treat CML by inhibiting BCR-ABL tyrosine kinase?
• In caring for a child with hemophilia, which history finding would you expect?
• Which is a common symptom of anemia in children?
• Which statement about platelet levels in newborns is true?
• Which triad best describes extremity symptoms in sickle cell disease?